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KMID : 0378020080510030036
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New Medical Journal
2008 Volume.51 No. 3 p.36 ~ p.43
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A Clinial Study of Lactobacillus Acidophilus in Acute Watery Diarrhea in Children
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Park Ihi-Sung
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Abstract
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Purpose: Acute diarrhea is a major problem in children worldwide. But there are no effective drug for the treatment of acute diarrhea in children. I want to know the effect of Lactobacillus LB for the treatment of acute diarrhea. So, I evaluated the clinical efficacy of orally administered Lactobacillus LB for the treatment of acute diarrhea in children.
Methods: From September 2007 to February 2008 at Soonchunhyang University Gumi Hospital 40 children aged from 3 months to 5 years with acute diarrhea were enrolled in this study. The patients were randomized to one of two groups to receive either 0.5×108 colony forming unit of Lactobacillus LB or matching placebo on admission and every 8
hours during hospitalization.
Results: The mean duration of watery diarrhea after initiation of treatment was 3.1 days in the Lactobacillus LB (n=20) vs. 3.8 days in the placebo group (n=20) (P=0.034). By the fourth day of treatment, watery diarrhea ceased in all patients receiving L. acidophilus LB compared to 30 percent of those reciving placebo (P=0.008).
Conclusion: L. acidophilus LB seems to be an effective therapeutic agent in acute diarrhea in children. Further studies are needed with more patients to confirm the present findings.
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KEYWORD
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Probiotics, Lactobacillus acidophilus, Acute diarrhea
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